It was a week for the ‘dogs. Across the 14 matchups, the underdogs went 9-4-1 against the spread (ATS), and seven won straight up. The totals split 5-5, while the league delivered three overtime games and major upsets by Tennessee, Carolina, Cleveland, Houston, Arizona, and New Orleans. It’s chaos, and bettors need to focus on the matchup, not the record, before wagering on NFL Week 7 odds.
The schedule includes New England at Chicago on Thursday Night Football, the NFL’s first game in Paris with Pittsburgh facing New Orleans, one Sunday Night Football matchup between two contenders, and an always-heated NFC East battle on Monday.
*All spreads, moneylines, and totals are subject to change.
Check the latest odds at Bovada.
NFL Week 7 Games to Watch
Thursday, Oct. 22: New England Patriots at Chicago Bears – 8:15 p.m. ET, Prime Video
- Spread: Bears -3
- Moneyline: Patriots +140; Bears -165
- Total: 51
New England has won three straight after beating the Jets 26-19, but a short week magnifies its growing injury list. Seventeen players are on the injury report, including wide receiver Romeo Dobbs (IR, shoulder injury); much of the offensive line is banged up; and WR AJ Brown is dealing with an ankle injury after a shaky return.
Does that open the door for Chicago at home? Quarterback Caleb Williams returned in Week 6 and immediately made a difference with a 31-23 win over Atlanta, and he’s already cleared for Thursday. The 51-point total suggests both offenses will keep rolling.
Check the latest Bears vs. Patriots odds and picks before Thursday’s kickoff.
Sunday, Oct. 25: Pittsburgh Steelers vs. New Orleans Saints – 9:30 a.m. ET, NFL Network
- Spread: Steelers -3.5
- Moneyline: Steelers -195; Saints +165
- Total: 44
The NFL’s first regular-season game in Paris brings two Week 6 winners to the Stade de France. Aaron Rodgers led Pittsburgh back from a 16-3 fourth-quarter deficit to beat Tampa Bay in overtime, while New Orleans scored 34 unanswered points to beat the Giants. With all that’s going on in Paris, this neutral matchup may come down to who gets a good night’s sleep amidst all the chaos.
Check the latest Saints vs. Steelers odds and picks before kickoff in Paris.
Sunday, Oct. 25: Cincinnati Bengals at Baltimore Ravens – 1 p.m. ET, CBS
- Spread: Ravens -3
- Moneyline: Bengals +130; Ravens -150
- Total: 51
Baltimore allowed only 13 points last week but still lost in London on a final-second field goal. They’re praying QB Lamar Jackson returns to get the offense back on track.
Cincinnati enters rested after its bye, setting up a tough divisional matchup for a Ravens team now tied with Cleveland and Pittsburgh at 4-2. The high total suggests oddsmakers expect Baltimore’s offense to rebound rather than repeat last week’s 10-point performance.
Check the latest Ravens vs. Bengals odds and picks before kickoff.
Sunday, Oct. 25: Indianapolis Colts at Minnesota Vikings – 1 p.m. ET, CBS
- Spread: Vikings -6
- Moneyline: Colts +225; Vikings -275
- Total: 41.5
The Colts are in shambles. Indianapolis has lost two straight after committing three turnovers and allowing a blocked-punt touchdown against a winless Tennessee team. Cornerback Sauce Gardner is also week-to-week with a calf strain, and the team fired the general manager who gave up two first-round picks to land him.
Minnesota is rested, undefeated, and favored by six in a matchup where its defense can pressure Daniel Jones into another mistake-heavy afternoon.
Check the latest Vikings vs. Colts odds and picks before kickoff.
Sunday, Oct. 25: Green Bay Packers at Detroit Lions – 4:25 p.m. ET, FOX
- Spread: Lions -3
- Moneyline: Packers +150; Lions -175
- Total: 53.5
After a shaky start, the Packers are rolling behind QB Jordan Love. They’ve won two straight and just held Dallas to 13 points despite edge Micah Parsons remaining sidelined. Love is in the MVP conversation with 11 touchdowns and just 4 INTs, and he faces a Detroit Lions team that hasn’t had an under all season.
Another shootout signal: the Lions are coming off a bye, led by QB Jared Goff, who is also in the MVP convo with 12 TDs and no INTs.
Check the latest Lions vs. Packers odds and picks before kickoff.
Sunday, Oct. 25: Kansas City Chiefs at Seattle Seahawks – 8:20 p.m. ET, NBC
- Spread: Seahawks -2.5
- Moneyline: Chiefs +120; Seahawks -140
- Total: 42.5
The most surprising line makes undefeated Kansas City a road underdog against 3-3 Seattle. The Chiefs have allowed only six points in their last two games, while Sam Darnold leads the NFL with seven interceptions after another costly mistake in Denver. Seattle may regain guard Anthony Bradford, but Patrick Mahomes at plus money will attract attention.
Check the latest Chiefs vs. Seahawks odds and picks before Sunday Night Football.
Monday, Oct. 26: Dallas Cowboys at Philadelphia Eagles – 8:15 p.m. ET, ESPN
Spread: Cowboys -4.5
Moneyline: Cowboys -225; Eagles +185
Total: 44
Philadelphia’s fourth straight loss was overshadowed by the news that Jalen Hurts will miss the rest of the season while being treated for blood clots in his lungs. Tanner McKee now takes over an offense already missing several important pieces. Dallas has lost two straight, but Dak Prescott and the Cowboys are favored on the road with Philadelphia’s difficult situation.
Check the latest Cowboys vs. Eagles odds and picks before Monday Night Football.
Key Players to Watch in NFL Week 7
These players could perform above or below expectations because of matchup, role, or recent form.
Patrick Mahomes, QB, Kansas City Chiefs – Better Than Expected: The 5-0 Chiefs are rare underdogs, yet Seattle has lost two straight and may need Darnold to chase points. Mahomes offers more upside than the low 42.5-point total suggests.
Jordan Love, QB, Green Bay Packers – Better Than Expected: Love enters with consecutive wins and faces a Detroit secondary still reintegrating Branch. The slate’s highest total creates favorable passing and touchdown expectations.
Daniel Jones, QB, Indianapolis Colts – Lower Than Expected: Jones threw two interceptions against Tennessee and now faces an undefeated, rested Minnesota defense. Indianapolis may lean heavily on Jonathan Taylor to reduce the QB’s exposure.
NFL Week 7 Betting Trends
Quick tips and trends for NFL Week 7 against the spread, moneyline, and total.
- Last week, underdogs went 9-4-1 ATS. Seven underdogs won straight up. The push was New England over the New York Jets by seven.
- In 2025, favorites rebounded in Week 7 last season, going 12-3 straight up and 10-5 ATS after finishing only 7-8 ATS in Week 6.
- Week 6 totals continued the trend of being balanced, going 7-7.
- Since 2020, the Kansas City Chiefs have covered 75% of their matchups where they open as an underdog on the road. They’re underdogs at Seattle.
- Since 2020, the Baltimore Ravens have covered in 65% of their matchups after a straight-up loss.
- Houston is Week 7’s largest listed favorite, dancing between -9.5 and -10. Green Bay-Detroit has the highest total at 53.5 with five straight overs.
NFL Week 7 FAQs
When does NFL Week 7 begin?
Week 7 begins Thursday, October 22, when New England visits Chicago at 8:15 p.m. ET.
Where can I bet on NFL Week 7?
Bovada offers NFL Week 7 odds including spreads, moneylines, totals, and player props. Same-game parlays also earn double reward points for four or more same-game picks.
Which teams are undefeated entering Week 7?
San Francisco is 6-0, while Kansas City and Minnesota are 5-0. All three teams play in Week 7.