NFL Week 6 Odds and Betting Lines

Week 6 of the NFL season kicks off this Thursday and we can’t wait.

The NFL is a third of the way through the season. Teams that were expected to shine (Baltimore, San Francisco) aren’t exactly rolling just yet, while others that had big odds against them (Minnesota, Washington) continue to rack up W’s.

Ready for this week’s NFL action and some of the best odds* in the game? We are, and we’ve got some great betting insights to take you to the next level.

NFL Odds

View the latest NFL odds at Bovada

San Francisco 49ers (-170) at Seattle Seahawks (+145)

With close to 200 bets available for San Francisco vs Seattle on Thursday Night Football, there are plenty of ways to look at the NFL odds for this important NFC West game.

Both teams are banged up at the moment, so the short rest after Week 5 won’t help (or hurt) either one.

The Seahawks’ defense is hobbled even more than the Niners’ offense though, which likely gives SF the edge in the moneyline at the moment, even though they’re playing in front of a tough Seattle crowd.

Seattle is coming off a loss to the New York Giants, which undoubtedly gives oddsmakers a reason to question how ready the team is to face a San Fran team that still put up close to 400 yards of offense in a losing effort of their own.

The Seattle secondary gave up 250 yards and 2 TDs to Daniel Jones, and that was without his #1 WR Malik Nabers.

But this isn’t the below-average NY Giants coming to town. How will Niners stars like Brock Purdy, Brandon Aiyuk and George Kittle do? It could be a long night for Seahawks fans.

Jacksonville Jaguars (+115) at Chicago Bears (-130)

Signs of life emerged from both the Jags and the Bears last weekend, so it’ll be an interesting game as the teams square off across the ocean.

As with any London game, home-field advantage doesn’t really play a factor, so it’s best to evaluate both teams straight up.

Bears’ rookie QB Caleb Williams had something of a coming-out party this past weekend, throwing for over 300 yards and 2 TDs, but it was against the Panthers. Still, he looked sharp and connected with his star receivers often.

Meanwhile the Jags showed they’re not completely toothless, picking up their first win of the season as Trevor Lawrence racked up 370+ yards and running back Tank Bigsby picked over 100 yards on just 13 carries.

It may come down to which defense can get the job done. In that case, the Bears’ D is seventh-best in the league in terms of yardage allowed, while Jacksonville is 31^st.

With hundreds of bets – including slim moneyline odds currently in favor of Chicago – the Bears-Jaguars game in London will be any bettor’s cup of tea…

Washington Commanders (+235) at Baltimore Ravens (-285)

Two of the most electric quarterbacks in the NFL go head-to-head in NFL Week 6 as Washington heads to Baltimore.

The Commanders’ NFL odds have taken a sharp turn towards making the playoffs this year, with their amazing rookie QB Jayden Daniels putting up 30+ points per game. In fact, they’ve scored below 34 points just once in their first five games this season.

When it comes to the Ravens, it’s tough to know which version of the team will show up. Two of their 3 wins on their current streak have come by just 3 points each, and they just gave up 38 points to the Bengals and needed a late comeback to pull out the win.

With that in mind, the current Ravens-Commanders spread of 6.5 points in favor of Baltimore seems high and could come down during the week.

But Ravens’ QB Lamar Jackson – the reigning league MVP – is capable of singlehandedly taking over a game when they need points in crunch time.

All the Commanders-Ravens bets you need are here at Bovada. And with Jackson and Daniels calling the shots and making big plays, be sure to check out the Prop Builder tool below all the listed NFL games too.

Detroit Lions (-3.5) at Dallas Cowboys (+3.5)

This is close to being the marquee matchup on the NFL Week 6 schedule.

The Lions have found their footing after a shaky start to the season, and they’re still set on a return to the playoffs after coming so close to the Super Bowl last season.

Detroit is coming off a bye week too, while the Cowboys played late on Sunday night and into Monday’s early hours in a last-second win over Pittsburgh last weekend.

Lions’ QB Jared Goff averaged a crazy 16 yards per pass in their most recent win over Seattle, and he’s got all his weapons loaded. Wide receivers Amon-Ra St. Brown and Jameson Williams are healthy and the running back duo of David Montgomery and Jahmyr Gibbs have the Lions as the 6^th-best running team in the league.

Contrast that with a Dallas defense that is missing Micah Parsons and several other key players. They’re 24^th in run defense at the moment.

If the game turns into an offensive shootout, Dallas can counter with their own star WR CeeDee Lamb and an emerging RB in Rico Dowdle, who ran for 87 yards against the Steelers and is getting more touches every game.

Three of the Cowboys’ games this season have hit the Over, so even if the current O/U is a hefty 52.5, NFL betting fans might like to go higher.

Buffalo Bills (-130) at New York Jets (+150)

Aaron Rodgers returns to his new home in the Big Apple as Josh Allen and the Bills come to town for Monday Night Football.

Lots of eyes will be on this game, along all 190+ NFL odds for the Bills-Jets game at Bovada, since it’s a crucial AFC East rivalry.

Rodgers comes into the game with some question marks, however. Will jet lag from playing in London be a factor? How much is the sprained ankle that he sustained in that loss to the Vikings going to impact his mobility?

Adding to the team’s concerns, running back Breece Hall – number one on many fantasy leagues’ rosters before the season – has not produced as expected, and there are concerns about head coach Robert Saleh’s ability to finish the season in his current job.

Given these factors and the Jets’ uneven 2-3 performance so far this season, the current moneyline of +150 may look a little light for the Jets, or a little low (-130) for the Bills.

Then again, Buffalo QB Josh Allen got dinged up quite badly with a hit in last weekend’s loss to the Houston Texans, and the Bills are on a two-game skid of their own. Allen finished 9-for-30 in passing in that Texans game, and aside from RB James Cook who continues to, well, cook, Buffalo’s offense isn’t looking as sharp as it did in September.

How about a nice Sports Welcome Bonus for you newcomers to Bovada? Making that first deposit with crypto will get you even more cash to play with.  Whether you’re new or you’re one of our faithful players, this Week 6 NFL odds are all ready at Bovada.

*Odds subject to change

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