Nothing’s more fun than betting on the NFL. Unfortunately, it may be because it’s the hardest sport to predict. Four underdogs won straight up, the Giants and Commanders tied 27-27, and both Monday games went to overtime. Despite the upsets, favorites finished 8-6-1 ATS, and seven of 13 available totals went over. The numbers say that, more than ever, a clear understanding of NFL betting stats is essential to be on the right side of NFL Week 6 odds.
San Francisco and Minnesota are 5-0; 4-0 Kansas City returns from its bye, while Minnesota, Cincinnati, Detroit, and Miami take a Week 6 break. That gives us a 10-game schedule starting with Seattle at Denver on Thursday, Houston and Jacksonville in London, and Washington at San Francisco on Monday night. Here are the games to watch and the latest NFL Week 6 betting trends.
*All spreads, moneylines, and totals are subject to change.
View the latest NFL odds at Bovada
NFL Week 6 Games to Watch
Thursday, Oct. 15: Seattle Seahawks at Denver Broncos – 8:15 p.m. ET, Prime Video
- Spread: Seahawks -3
- Moneyline: Seahawks -160; Broncos +135
- Total: 41
Seattle’s 32-29 loss to San Francisco included four turnovers, which is a major concern with Denver’s elite defense up next on a short week. Sam Darnold needs to protect the ball against a Broncos defense that produced two late takeaways in a 23-17 win over the Chargers. Seattle’s underrated engine last year was the run game, but it has underwhelmed in 2026. Running back Zach Charbonnet is still sidelined with a knee injury, and rookie Jadarian Price is on injured reserve. Emanuel Wilson will once again have to pace the offense; he’s averaged just 3.4 yards on 73 carries.
Check the latest Broncos vs. Seahawks odds and picks before Thursday’s kickoff.
Sunday, Oct. 18: Houston Texans vs. Jacksonville Jaguars – 9:30 a.m. ET, NFL Network
- Spread: Jaguars -2.5
- Moneyline: Texans +125; Jaguars -145
- Total: 42.5
Jacksonville improved to 4-1 after Trevor Lawrence threw for 331 yards in a 19-17 win over Philadelphia. Houston finally broke through with a 26-3 win over Tennessee, as C.J. Stroud completed 26 of 34 passes for 261 yards. This sets up a great AFC South QB battle on neutral ground (Wembley Stadium).
With just a -2.5 spread, oddsmakers see the matchup as fairly even despite the teams’ opposite records. Check the latest Texans vs. Jaguars odds and picks before kickoff.
Sunday, Oct. 18: Carolina Panthers at Philadelphia Eagles – 1 p.m. ET, CBS
- Spread: Eagles -1
- Moneyline: Panthers -105; Eagles -115
- Total: 41.5
Philadelphia has dropped three straight after opening 2-0, and its running backs totaled only 22 yards against Jacksonville.
They’re in desperation mode with a home crowd behind them. However, oddsmakers have made them just -1 favorites, as Carolina has become an offensive force the Eagles might not be able to match.
Check the latest Panthers vs. Eagles odds and picks before kickoff.
Sunday, Oct. 18: Pittsburgh Steelers at Tampa Bay Buccaneers – 1 p.m. ET, CBS
- Spread: Steelers -3
- Moneyline: Steelers -150; Buccaneers +130
- Total: 40.5
We guess there’s juice left in that old arm after all. Aaron Rodgers has thrown three touchdown passes in three consecutive games, and Jaylen Warren produced 188 scrimmage yards and two scores against Indianapolis. Their impressive run has them in oddsmakers’ good graces again, opening as road favorites at Tampa Bay.
Tampa Bay earned its first win behind 165 rushing yards from Bucky Irving, but Baker Mayfield remains out, and safety Antoine Winfield Jr. is doubtful. Check the latest Steelers vs. Buccaneers odds and picks before kickoff.
Sunday, Oct. 18: Los Angeles Chargers at Kansas City Chiefs – 4:25 p.m. ET, CBS
Spread: Chiefs -8.5
Moneyline: Chargers +325; Chiefs -435
Total: 42
Kansas City returns from its bye as the NFL’s only 4-0 team and the board’s biggest favorite. They face the Chargers, who are desperate for a win, but the schedule is doing them no favors with a well-rested Patrick Mahomes and Travis Kelce at home.
Check the latest Chargers vs. Chiefs odds and picks before kickoff.
Sunday, Oct. 18: Dallas Cowboys at Green Bay Packers – 8:20 p.m. ET, NBC
- Spread: Packers -1
- Moneyline: Cowboys -105; Packers -115
- Total: 53
This matchup has the highest total as Dallas’ defense ranks 27th in points allowed (27.2), second-last in passing yards allowed, and dead last in rushing yards allowed. It doesn’t help that Packers QB Jordan Love had his best game last week, passing for 367 yards and finding Christian Watson for two long touchdowns. Meanwhile, Dak Prescott and the Cowboys offense threw two interceptions in a shocking 24-16 home upset against Tampa Bay.
Check the latest Cowboys and Packers odds and picks before kickoff.
Monday, Oct. 19: Washington Commanders at San Francisco 49ers – 8:15 p.m. ET, ESPN/ABC
- Spread: 49ers -7.5
- Moneyline: Commanders +300; 49ers -400
- Total: 50.5
Washington’s clock management in overtime overshadowed a solid return for QB Jayden Daniels. He finished with 199 passing yards, 103 rushing yards, and two touchdowns in an odd 27-27 tie with the New York Giants. The task gets tougher with 5-0 San Francisco next. Once again, the 49ers will be short-handed (WR Deebo Samuel is out indefinitely with a hamstring injury), but oddsmakers obviously don’t think that will slow them down.
Check the latest Commanders vs. 49ers odds and picks before kickoff.
Key Players to Watch in NFL Week 6
These players could perform above or below expectations because of matchup, role, or recent form.
- Aaron Rodgers, QB, Pittsburgh Steelers – Better Than Expected: Rodgers has 10 touchdown passes through five games and faces a Tampa Bay secondary likely to be without Winfield. His recent red-zone efficiency could continue even if the low total limits overall yardage.
- Jaylen Warren, RB, Pittsburgh Steelers – Better Than Expected: Warren turned 21 touches into 188 yards last week and remains dangerous as both a runner and receiver. That workload gives him more upside than a typical lead back in a game Pittsburgh is favored to control.
- Sam Darnold, QB, Seattle Seahawks – Lower Than Expected: Darnold threw two interceptions in Seattle’s four-turnover loss. A Thursday road game at altitude against an opportunistic Denver defense creates another difficult environment for passing efficiency.
NFL Week 6 Betting Trends
Quick tips and trends for NFL Week 6 against the spread, moneyline, and total.
Andy Reid is 8-11 ATS after the bye since he became their head coach. The Chiefs have the largest spread this week at -8.5.
Favorites went 8-6-1 ATS in Week 5, but four underdogs won straight up.
Seven of the 13 Week 5 games went over; six went under.
Buffalo, Las Vegas, Minnesota, the New York Giants and San Francisco 49ers all have 80% ATS win rates after five games.
After Week 5, the San Francisco 49ers are covering spreads by an average of 8.8 points.
Detroit’s bad defense and dominant offense make them a force on the over with a perfect 5-0 record.
In Week 6 last season, favorites went 11-4 straight up but only 7-8 ATS.
Unders went 9-5-1 in Week 6 last year after overs finished 9-5 in Week 5, a sharp one-week reversal.
NFL Week 6 FAQs
When does NFL Week 6 begin?
Week 6 begins Thursday, October 15, when Seattle visits Denver at 8:15 p.m. ET.
Where can I bet on NFL Week 6?
Bovada offers NFL Week 5 odds including spreads, moneylines, totals, and player props. Same-game parlays also earn double reward points for four or more same-game picks.
Which teams are undefeated entering Week 6?
Minnesota and San Francisco are 5-0, while Kansas City is 4-0 after its Week 5 bye. Minnesota is off in Week 6.
*Odds subject to change