NFL Week 16 Odds and Betting Lines

After another wild week that saw tons of turnovers and plenty of points on the board,
Week 16 in the NFL is ready to go.

The playoff window is closing every week, and many teams are playing to stay in the hunt.  

We’ve got games on Thursday, Saturday, and Sunday (and that’s just this week – wait till you see the lineup for Christmas week…).

Read on for some of best ways to play the NFL odds for Week 16…

NFL Odds

View the latest NFL odds at Bovada

Denver Broncos (+135) at Los Angeles Chargers (-160)

This Thursday Night Football showdown between the Broncos and the Chargers has plenty of playoff implications.

The Chargers are coming off a rough outing against Tampa Bay, giving up the most points and the most yardage that they’ve allowed all season. They were outscored 27-0 in the second half and gave up over 500 yards overall. Is this an ominous sign heading into a short week, or a wake-up call for a normally very solid D?

Still, they can clinch a playoff spot with a win in this game plus one more before the end of the season. This makes this game a crucial one for the Bolts.

They might also be able to re-group fast if Bo Nix looks shaky again. The Broncos’ rookie QB threw for just 130 yards and was picked off 3 times last weekend, so he’ll also have to turn the page quickly this week.

Even though Denver has a slightly easier path to the playoffs – their chance of making the postseason is 94% – this isn’t a game they can play on cruise control. They will clinch a playoff spot with a win against the Chargers.

Keep an eye on Justin Herbert’s health too, with little time to recover before Thursday rolls around. The Chargers 3-point edge in the spread could be vulnerable if Herbert isn’t close to 100%, especially if their defense takes another week off.

Beyond the spread, we’ve got over 230 bets to play for the Broncos-Chargers game.

Pittsburgh Steelers (+225) at Baltimore Ravens (-275)

If the Baltimore Ravens win this Saturday matchup, their NFL odds for making the playoffs will sit at 100% (aka the Ravens will clinch a spot with a win).

They’re also playing for home field advantage and the division title. With these extra motivators the NFL oddsmakers currently have them as 6.5-point favorites over the Steelers.

Did Pittsburgh finally get exposed in their lopsided loss to the Eagles last weekend?

With a one-dimensional passing game that consists mainly of George Pickens (when he even plays) and a defense that relies heavily on T.J. Watt (who could be out for this game), their 10-4 record could be a little deceiving.

Baltimore is coming off a relatively easy week too, handling the Giants 35-14. And if Jalen Hurts can hang 290 yards on the Steelers’ secondary, what can Lamar Jackson do, especially if Watt can’t play? The reigning NFL MVP had 5 TDs last weekend to go along with just 4 incompletions. The Ravens are at home too.

This will be a different ball game than the one these two AFC North teams played just four weeks ago, when the Steelers won 18-16.

Catch all the Steelers-Ravens odds, props, and more at Bovada.

Philadelphia Eagles (-185) at Washington Commanders (+160)

Speaking of teams in the hunt for #1 in their conference, the Eagles are also in the conversation.

They’re coming off a gritty win over their home state rivals last weekend. After a couple of poor showings on offense, QB Jalen Hurts bounced back in a big way with close to 300 yards passing and 2 TDs against a normally tough Steelers defense.

Eagles’ MVP candidate RB Saquon Barkley had a relatively quiet week, but he could explode against a Commanders’ rushing defense that ranks 25^th in the league.

On Washington’s side of the ball, rookie sensation QB Jayden Daniels has slowed down since a mid-season injury and is showing some mixed signals. He did complete 80% of his passes in the win over the Saints last weekend, but he also took 8 sacks. A more talented defense like Philly’s could make life very difficult for Daniels.

In the teams’ earlier tilt just 4 weeks ago, the Eagles came out on top 26-18, with Barkley rushing for 146 yards and 2 touchdowns.

Despite that, plus the Commanders barely squeaking out a win against the Saints, the spread is just 3.5 points in favor of Philadelphia. The Eagles to cover and going with the over  (currently the O/U is 46.5) could be decent plays, especially if Saquon goes off again.

Play hundreds of lines, odds, and props for the Eagles vs. Commanders game this weekend.

San Francisco 49ers (+120) at Miami Dolphins (-140)

Before their snakebit season started, the San Francisco 49ers did not expect to be on the outside looking in on the NFL Playoffs race this late in the season.

The Niners need a lot of help to make it into the postseason, but they should still come out playing hard against a Dolphins squad that is also fighting for a slim chance to be playing in mid-January.

The Dolphins are a puzzle. Their rushing talent hasn’t produced a 100-yard game in six straight outings, and their fleet wide receivers Tyreek Hill and Jaylen Waddle have disappointed fans (and fantasy league owners) all year.

The 49ers are equally puzzling. As they showed in a 38-13 win over the Bears two weeks ago, they can still put up points with all their firepower on offense. But that was their only green in a sea of red, going 1-4 over their last 5 games.

If the Fins tap out early in the game as they often seem to do, watch for the Niners – on 10 days’ rest – to put up some serious points and avenge their recent 6-point performance in a water-logged loss to the Rams. They could easily cover their +2.5 point spread and also put test the over for the 46-point O/U.

There are 200+ ways to wager on the 49ers-Dolphins game right now at Bovada.

Tampa Bay Buccaneers (-210) at Dallas Cowboys (+175)

Baker and the Bucs are headed to Big D with a bit of momentum.

They’re coming off a 40-17 crushing of the LA Chargers, a game in which they racked up over 500 yards on offense. It was Tampa’s 4^th straight win (although the previous three games were against the Giants, Panthers, and Raiders).

They Cowboys can be sneaky though. Yes, it was against the Panthers, but they did put up over 400 yards of total O themselves. Home underdogs can come up big, especially with a healthy Micah Parsons pressuring Baker Mayfield and their slimmest of playoff hopes still alive.

But back to Tampa. If Mayfield can limit his interceptions (he’s thrown 14 this season) and WR Mike Evans shines against a depleted Cowboys’ secondary, they could eliminate the Cowboys and cover their current -4.0 spread. Remember, despite the easy opponents of late, this is the same Bucs team that has also beaten the NFC’s top two teams this season, Detroit and Philadelphia.

Play hundreds of bets on the Tampa Bay vs. Dallas game on Sunday Night Football.

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*Odds subject to change

All NFL Matches in Week 16