Arizona Cardinals
San Francisco 49ers
Kickoff: 4:05 PM
Levi’s Stadium, Santa Clara
Match Facts
- League
- National Football League
- Week
- Week 3
- Date
- 09/27/2026
- Venue
- Levi's Stadium
| 09/27/2026 4:05 PM | Spread | Win | Total |
|---|---|---|---|
| Arizona Cardinals | +8.5-115 | +305 | o 48-110 |
| San Francisco 49ers | -8.5-105 | -410 | u 48-110 |
The San Francisco 49ers are -8.5 favorites over the Arizona Cardinals in Week 3 at Levi's Stadium, with the total set at 48 points. That's the scene for a Sunday afternoon NFC West get-together that has the makings of a true house party - two rivals, a packed stadium, and a full slate of storylines. San Francisco is perfect through two weeks, while Arizona is looking to steady itself after a rough outing in Seattle.
49ers (2-0) host Cardinals (1-1) in an NFC West divisional clash at Levi's Stadium, with San Francisco looking to keep rolling.
Head-to-Head
| Date | Result | Venue |
|---|---|---|
| 11/16/2025 | San Francisco 49ers 41 @ 22 Arizona Cardinals | at Arizona Cardinals |
| 09/21/2025 | Arizona Cardinals 15 @ 16 San Francisco 49ers | Levi's Stadium, Santa Clara |
Key Stats Comparison
Record (2026/27)
Arizona Cardinals 1-1 - San Francisco 49ers 2-0
Points Scored (2026/27)
Points Allowed (2026/27)
Rushing Yards / Game
Passing Yards / Game
Turnovers / Game
The matchup and stakes
This is Week 3 of the regular season, and the NFC West is already taking shape. San Francisco can move to 3-0 with a win, while Arizona is aiming to get back to .500 after a tough loss in Seattle. A divisional win this early sets the tone for the rest of the year, and the energy at Levi's Stadium should be something else.
Form and records
San Francisco has been sharp, allowing just 20 points while scoring 62 in its two wins. The last five games, including the tail of last season, read W-W-L-W-L. Arizona split the first two weeks, beating the Chargers 26-14 before falling to the Seahawks 31-7, and its last five are L-W-L-L-L. Both teams have shown flashes, but the 49ers have the cleaner start.
The line
The 49ers are an 8.5-point favorite at home, a nod to their form and the Cardinals' uneven start. The total is set at 48 points, a number that reflects the contrast between San Francisco's efficient passing attack and Arizona's road struggles. The market clearly expects the home side to control the afternoon.
Head-to-head history
These two met twice last season. At Levi's Stadium in Week 3, the 49ers edged the Cardinals 16-15. Then in Week 11 in Arizona, San Francisco won 41-22. The most recent meeting was a decisive road win for the team hosting this week.
What to watch
Watch how the Cardinals' offense responds after a quiet outing in Seattle, and whether the 49ers can extend their perfect start. There's plenty on the table for both sides, and with a full house expected, this one has the feel of a proper get-together. Pull up a chair and see how it plays out.
When is the game and where is it played?
The game kicks off at 4:05 PM ET on Sunday, September 27, 2026, at Levi's Stadium in Santa Clara, California.
What are the records of the 49ers and Cardinals coming in?
The 49ers are 2-0, while the Cardinals are 1-1.
Who won the last game between these two teams?
The 49ers beat the Cardinals 41-22 in their most recent meeting, which took place in Arizona on November 16, 2025.
What has been the recent form for each team?
San Francisco has won each of its first two games this season, while Arizona split its first two. Over the last five games including the prior season, the 49ers are W-W-L-W-L and the Cardinals are L-W-L-L-L.
Is this a divisional matchup?
Yes, both teams are in the NFC West, so this is a key early division game.
Next Match
Week 3 · Levi's Stadium · Arizona Cardinals vs San Francisco 49ers
View matchup
Regular Season NFL match-ups by week 272 games ▾
▼ Week 1 16 games
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Wed, Sep 9 |
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Thu, Sep 10 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Sun, Sep 13 |
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Mon, Sep 14 |
▼ Week 2 16 games
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Thu, Sep 17 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Sun, Sep 20 |
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Mon, Sep 21 |
▼ Week 3 16 games
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Thu, Sep 24 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Sun, Sep 27 |
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Mon, Sep 28 |
▼ Week 4 16 games
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Thu, Oct 1 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Sun, Oct 4 |
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Mon, Oct 5 |
▼ Week 5 15 games
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Thu, Oct 8 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Sun, Oct 11 |
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Mon, Oct 12 |
▼ Week 6 14 games
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Thu, Oct 15 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Sun, Oct 18 |
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Mon, Oct 19 |
▼ Week 7 14 games
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Thu, Oct 22 |
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Sun, Oct 25 |
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Mon, Oct 26 |
▼ Week 8 14 games
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Thu, Oct 29 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Sun, Nov 1 |
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Mon, Nov 2 |
▼ Week 9 15 games
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Thu, Nov 5 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Sun, Nov 8 |
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Mon, Nov 9 |
▼ Week 10 14 games
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Thu, Nov 12 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Sun, Nov 15 |
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Mon, Nov 16 |
▼ Week 11 13 games
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Thu, Nov 19 |
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Sun, Nov 22 |
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Sun, Nov 22 |
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▼ Week 12 16 games
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Wed, Nov 25 |
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Thu, Nov 26 |
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Fri, Nov 27 |
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Sun, Nov 29 |
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▼ Week 13 14 games
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Thu, Dec 3 |
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Sun, Dec 6 |
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Sun, Dec 6 |
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Mon, Dec 7 |
▼ Week 14 15 games
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Thu, Dec 10 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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Sun, Dec 13 |
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▼ Week 15 16 games
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Thu, Dec 17 |
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Sat, Dec 19 |
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Sat, Dec 19 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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Sun, Dec 20 |
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▼ Week 16 16 games
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Thu, Dec 24 |
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Fri, Dec 25 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Sun, Dec 27 |
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Mon, Dec 28 |
▼ Week 17 16 games
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Thu, Dec 31 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Sun, Jan 3 |
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Mon, Jan 4 |
▼ Week 18 16 games
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |
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Sun, Jan 10 |