What a wild weekend. Will the NFL Division Round odds provide the same action?
There was only one blowout in the Wild Card round, with Houston sending Aaron Rodgers back to his ayahuasca retreat, and forcing head coach Mike Tomlin to resign after a 30-6 defensive dismantling. The other matchups? Nothing but fourth-quarter comebacks and nailbiters, a testament to the lack of a true favorite when looking at odds to win Super Bowl LX.
The Rams, Bears, 49ers, and Seahawks are left in the NFC. And the Texans, Bills, Patriots, and Broncos are in the AFC. Here’s a preview of the NFL Divisional Round and their odds.
View the latest NFL odds at Bovada
Saturday, January 17, 2026
Buffalo Bills (12-5) at Denver Broncos (14-3)
- Start: 4:30 p.m. ET on CBS
- Spread: Broncos -1, Bills +1
- Moneyline: Broncos -105, Bills -105
- Total: 46.5
Can your quarterback make plays? Can he survive? Josh Allen did both. He outlasted the Jacksonville Jaguars, absorbed multiple big hits, shook off injuries, and still delivered a game-winning drive minutes after Jacksonville took the lead.
But the Bills go from the eighth-best defense in points against to the third. The Broncos have been dominant, second only to the Texans in total yards allowed and rushing yards against. Meanwhile, QB Bo Nix makes up for any shortcomings on offense with five fourth-quarter comebacks and seven game-winning drives.
The Broncos are going to try to stuff Bills running back James Cook III as Jacksonville did. But unlike the Jags, they’ll need to remain turnover-free to ensure Allen doesn’t have multiple opportunities to carry the offense.
While reigning MVP Allen lacks weapons besides a star RB, the Broncos lack a consistent offense to pair with their elite defense. There’s a reason for that one-point spread.
San Francisco 49ers (12-5) at Seattle Seahawks (14-3)
- Start: 8 p.m. ET on FOX
- Spread: Seahawks -7.5, 49ers +7.5
- Moneyline: Seahawks -380, 49ers +290
- Total: 45
This matchup deserved a trilogy. The battle for the NFC West is always heated, and the 49ers and Seahawks have been competitive for years, regardless of their records or rosters. The 49ers won the first battle with a 17-13 Week 1 win at Seattle, a defensive battle where both teams had two turnovers, but QB Brock Purdy outdueled Sam Darnold with two TDs.
They met again in Week 18, with Seattle getting the upper hand this time in a 13-3 win. This time, Seattle’s defense managed to hold Purdy to 127 passing yards with one INT and no touchdowns, sacking him three times. Darnold stayed turnover-free to secure the victory.
Both matchups went under the total, with both teams covering in their wins. With all the injuries to the Niners and Seattle getting a week of rest, oddsmakers made Seattle the biggest favorites of the weekend.
Sunday, January 18, 2026
Houston Texans (12-5) at New England Patriots (14-3)
- Start: 3 p.m. ET on ESPN/ABC
- Spread: Patriots -3.5, Texans +3.5
- Moneyline: Patriots -170, Texans +146
- Total: 40.5
The Texans are the best defense in the NFL and possibly the last decade. They generated -33.4 in expected points added (EPA), the fewest of any playoff defense in the last 10 years. With such a dominant defense and an ascending roster, it’s surprising that this is the first playoff win in franchise history.
The question is now, can it continue? While Houston dropped 30 on the Steelers at Acrisure Stadium, only 16 came from their offense. Texans QB C.J. Stroud had an interception and a whopping five fumbles, but luckily lost only two.
Patriots QB Drake Maye wasn’t much better against the Chargers, leading just one touchdown drive in a 16–3 win fueled by defense and a struggling Chargers offense. Despite their second-lowest output of the season, New England is still a three-point favorite against the Texans. Maye is more elusive than Rodgers, and it’s doubtful C.J. Stroud can repeat his Pittsburgh performance without the Patriots making him pay.
Los Angeles Rams (12-5) at Chicago Bears (11-6)
- Start: 4:30 p.m. ET on NBC/Peacock
- Spread: Rams -4, Bears +4
- Moneyline: Rams -210, +175
- Total: 49
If you didn’t believe in the nickname “Cardiac Bears” before, a fourth-quarter comeback down 15-plus would definitely cement it. Chicago shocked the world by beating rival Green Bay despite being down 18 points at halftime. They’ve been winning the same way all year: establish the run, be aggressive on fourth down, and unlock QB Caleb Williams scrambling ability and late-game down the stretch. The combination has given them an 11-7 record ATS and a chance to dethrone arguably the best team in the NFC.
While the Bears used youth and grit to make their run, the Rams have been steady and poised throughout the season. QB Matthew Stafford has been an MVP favorite all year, while wide receiver Puka Nacua has been the Swiss-Army Knife that makes the offense un-guardable. But they haven’t been indestructible; they needed a fourth-quarter drive to beat the 8-9 Panthers in the Wild Card round, and have struggled against teams that can run the ball effectively.