Week 5 delivered October’s first major poll shake-up. Missouri crushed then-No. 8 Florida 45-17, Alabama beat Mississippi State 56-23, and Ohio State handled Iowa 31-14. The College Football Week 6 odds bring Texas-Oklahoma, unbeaten Georgia-Alabama, and a ranked UCLA-Oregon matchup.
*All spreads, moneylines, and totals are subject to change.
College Football Week 6 Games to Watch
Saturday, Oct. 10: No. 1 Texas vs. Oklahoma – 3:30 p.m. ET ABC
• Spread: Texas -8.5
• Moneyline: Texas -330, Oklahoma +265
• Total: 39
Texas returns from its bye ranked No. 1 and undefeated, though its offense is still searching for consistency. Arch Manning has 862 passing yards, seven touchdowns, and three interceptions but hasn’t quite achieved the dominance expected from his name.
Oklahoma are +8.5 homedogs after scoring just 13 points against Georgia last weekend. Their run game is lacking, and senior quarterback John Mateer looks nothing like the player who was in early Heisman conversations last year.
Saturday, Oct. 10: Texas A&M at No. 14 Missouri – 12 p.m. ET ABC
• Spread: Texas A&M +3.5
• Moneyline: Texas A&M +155, Missouri -180
• Total: 48.5
Missouri’s 45-17 rout of Florida pushed the Tigers up 11 spots in the AP Poll. Running back Jamal Roberts rushed for 211 yards with three TDs against Florida, but Texas A&M’s defensive front came alive in a 34-7 rout against Arkansas. The Aggies will try to slow down Roberts and force senior QB Austin Simmons into long passing downs.
Saturday, Oct. 10: No. 21 UCLA at No. 13 Oregon – 3:30 p.m. ET CBS
• Spread: UCLA +12
• Moneyline: UCLA +350, Oregon -480
• Total: 60
UCLA is 4-0, but this is its first ranked opponent and true road test. Oregon enters rested after a bye and is planning for the return of star QB Dante Moore from a bad concussion versus USC.
As with any game involving Oregon, oddsmakers expect a shootout, with the largest total among our matchups.
Saturday, Oct. 10: No. 10 LSU at Kentucky – 7 p.m. ET ESPN
• Spread: LSU -8.5
• Moneyline: LSU -340, Kentucky +270
• Total: 54.5
LSU rebounded from its Ole Miss loss and now faces a Kentucky team coming off a 35-34 overtime comeback at South Carolina. The Tigers’ deeper receiving group can attack a vulnerable secondary; Kentucky needs a balanced offense to keep LSU’s pass rush from dictating the game.
Saturday, Oct. 10: No. 2 Georgia at No. 6 Alabama – 7:30 p.m. ET ABC
• Spread: Georgia +1.5
• Moneyline: Georgia -105, Alabama -115
• Total: 55.5
We’ve got an old SEC monster matchup. Both teams are 5-0 after pulling away from their SEC opponents last week. Alabama has won 10 of the past 12 meetings, but Georgia’s depth can challenge a Crimson Tide defense that has allowed explosive plays. Gunner Stockton and Keelon Russell face their biggest tests yet in a key matchup in the 2026-27 Heisman odds.
Saturday, Oct. 10: No. 19 USC at Penn State – 7:30 p.m. ET NBC
• Spread: USC +1
• Moneyline: USC -110, Penn State -110
• Total: 54
USC is 5-1 after surviving Washington, but its defense keeps opponents within reach. Penn State returns home after allowing 413 rushing yards in a 34-13 loss at Northwestern. The Nittany Lions have been outscored 58-16 across their past six-plus quarters, but the nearly EVEN odds suggest oddsmakers see a sneaky Penn State performance at Beaver Stadium.
Key Players to Watch in College Football Week 6
- Arch Manning, QB, Texas: The spotlight is always on Arch Manning, but Oklahoma’s solid pass defense could make or break his season.
- Keelon Russell, QB, Alabama: The freshman faces his toughest defense of the season.
- Gunner Stockton, QB, Georgia: His mobility is important against Alabama’s pressure. Stockton has a chance to move up the Heisman race with a star performance.
- Jeremiah Smith, WR, Ohio State: Smith already has nine touchdown catches and is running away with the Heisman race. Expect more dominance versus Maryland.
College Football Week 6 Betting Trends
These figures emphasize completed results and current market movement across spreads, moneylines, and totals.
- Favorites went 2-1 straight up and ATS in Week 5’s three ranked matchups. Alabama and Ohio State covered; Florida lost outright.
- Missouri delivered Week 5’s biggest ranked moneyline result, beating Florida by 28 points.
- Two ranked matchups went over: Alabama-Mississippi State reached 79 points, and Florida-Missouri reached 62. Ohio State-Iowa stayed under at 45.
- Another injury to the WR room has flipped Georgia-Alabama from Georgia -1.5 on the road to Alabama -1.5 at home.
- Texas-Oklahoma’s 39 is the lowest ranked total. Texas allows 13.3 points per game; Oklahoma scored 23 combined in its two losses.
AP Top 25 – Week 6
| RK | TEAM | REC | PTS | TREND |
| 1 | Texas (61) | 4-0 | 1737 | – |
| 2 | Georgia (6) | 5-0 | 1647 | – |
| 3 | Notre Dame | 5-0 | 1532 | – |
| 4 | Miami (2) | 5-0 | 1524 | – |
| 5 | Ohio State | 4-1 | 1490 | – |
| 6 | Alabama | 5-0 | 1460 | ↑1 |
| 7 | Indiana (1) | 5-0 | 1380 | ↓1 |
| 8 | BYU | 4-0 | 1144 | ↑2 |
| 9 | Ole Miss | 3-1 | 1095 | – |
| 10 | LSU | 4-1 | 1087 | ↑1 |
| 11 | Texas Tech | 5-0 | 1062 | ↑1 |
| 12 | Utah | 4-0 | 996 | ↑1 |
| 13 | Oregon | 3-1 | 831 | ↑2 |
| 14 | Missouri | 4-1 | 755 | ↑11 |
| 15 | Tennessee | 4-1 | 746 | ↑2 |
| 16 | Florida | 4-1 | 691 | ↓8 |
| 17 | Mississippi State | 4-1 | 487 | ↓1 |
| 18 | Oklahoma State | 3-1 | 477 | ↑1 |
| 19 | USC | 5-1 | 439 | ↓1 |
| 20 | Iowa | 4-1 | 367 | ↓6 |
| 21 | UCLA | 4-0 | 287 | ↑2 |
| 22 | Houston | 4-1 | 279 | ↓2 |
| 23 | Boise State | 4-1 | 271 | ↓1 |
| 24 | SMU | 4-1 | 167 | ↓3 |
| 25 | Pittsburgh | 5-0 | 162 | NR |
College Football Week 6 FAQs
When Does College Football Week 6 Begin?
Week 6 begins Tuesday, October 6, with Southern Miss visiting Troy at 7:30 p.m. ET on ESPN2.
What Is the Biggest College Football Week 6 Game?
No. 2 Georgia at No. 6 Alabama is the only matchup between two top-10 teams and carries immediate SEC and playoff importance.
Which College Football Week 6 Games Feature Ranked Teams?
Three games match AP Top 25 teams: Georgia-Alabama, Texas A&M-Missouri, and UCLA-Oregon.
Where Can You Bet on College Football Week 6?
Bovada’s college football page lists updated spreads, moneylines, totals, props, and futures. Same-game parlays also provide double the reward points for four same-game picks or more.