2025 College Football Week 10

It’s almost time for NCAA Football Week 10 and we have all the latest and greatest college football odds for dozens of NCAA games.

Just a few more weeks of regular season action remain, with CFP spots and conference titles on the line.

This week features another top-5 battle and “The World’s Largest Outdoor Cocktail Party”, just to name a few games.

Let’s look closer at the betting tips and insights for Week 10 in college football.

NCAAF Odds

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2024 Week 10 Colege Football

#4 Ohio State (-165) at #3 Penn State (+140)

It’s yet another huge game between two top-5 teams in NCAA football this season, and this one has plenty of drama even before kickoff.

Nittany Lions QB Drew Allar will be a game-time decision after being hurt last week. This could impact the Lions of course, but it also makes it tougher for the Buckeyes to prepare.

Penn State’s backup QB Beau Pribula did complete over 80% of his passes after Allar went down, so the team’s college football odds haven’t swung toward Ohio State as much as they could have.

Injury drama has affected Ohio State’s chances in this game too, as future pro LT Josh Simmons also went down last week and will not play. Against Penn State’s top-15 pressure rate defense, this could spell trouble for OSU QB Will Howard, who has struggled against pressure this season.

The final X factor? Penn State is 7-0 while OSU’s 6-1 record means they can’t afford another L if they want a top seeding in the College Football Playoff. The Buckeyes will come out firing.

Catch every bet for the Ohio State vs. Penn State game right here.

Florida (+550) at #2 Georgia (-850)

This is a classic matchup that’s been called “The World’s Largest Outdoor Cocktail Party” since the 1950’s. When it’s done this year, will Florida fans need a drink to celebrate or cope?

The Florida Gators will indeed be winding down this season with some positives for next year, even at 4-3 currently.

Freshman QB DJ Lagway is the highest-rated true frosh in the nation, and the team almost took down #7 Tennessee last weekend in an overtime loss.

The Gators would like to add to this good news by taking down the Bulldogs of course, but that might be too tough to pull off.

Georgia is 6-1 with their only loss coming to highly ranked Alabama, and that game came down to a miracle play to beat the Bulldogs.

Then again, Georgia QB Carson Beck hasn’t lived up to the Heisman hopes that he started the year with. He’s thrown for 5 interceptions in the past two games and has battled inconsistency all season.

Beyond the moneyline and the spread that heavily favor Georgia, there are dozens of bets available for the Florida-Georgia game at Bovada.

#1 Oregon (-750) at Michigan (+500)

Last season’s national champions must look at Oregon and remember the good ol’ days.

The new number-one team in the country for the past several weeks, Oregon, comes into this game as a 15.5-point favorite, a position neither team could have pictured at the start of the season.

The only thing going for the Wolverines this season where they’ve lost 3 games already, is their defense, which has given up just 21.5 points per game this season.

They’ll need all their defensive power against the Ducks’ Dillon Gabriel, currently among the Heisman Trophy leaders when it comes to college football odds for the NCAA awards. Especially considering the questionable status of the Wolverines’ elite corner Will Johnson.

While playing in Ann Arbor in front of 100,000+ fans isn’t easy, the Ducks might be just too much for a Michigan team that could already be looking toward next season.

With an Over/Under of 45 points, betting fans might like the Ducks, scoring over 30 points in all but one of their games this year and with all their current momentum, to take the score much higher.

#18 Pittsburgh (+255) at #20 SMU (-105)

Both of these top-25 teams have everything to play for in this ACC battle.

Despite just two spots separating the teams in the rankings, the college football odds for the Panthers/Mustangs game have Pittsburgh as a 7.5-point underdog currently.

What explains the big difference? Both teams have a perfect record in conference play so far this season, and Pittsburgh is 7-0 on the season. Plus, SMU barely beat Duke recently after a failed 2-point conversion.

Oddsmakers must like the Mustangs’ offense, which is 16^th in the entire country. But then, they had six turnovers last weekend alone. Meanwhile, Pitt handled Syracuse last weekend 41-13 on the strength of three pick-sixes.

Despite it being SMU’s homecoming game, which often gives the home team a boost, all signs seem to point to a closer game than the odds suggest.

Over 40 bets for the Pittsburgh-SMU game are ready to play right now.

#10 Texas A&M (-130) at South Carolina (+110)

The Texas A&M Aggies are in the top spot in the tough SEC. If they win their remaining games, they’ll clinch a spot in the CFP.

Backup QB Marcel Reed might be the one to take them all the way, given how well he played coming in to relieve Conner Weigman last week against a tough LSU team.

For the South Carolina Gamecocks, 19-year-old quarterback LaNorris Sellers can struggle when he’s pressed and may need to rely on his size and speed against a very tough Aggies D-line that features top NFL prospect Nic Scourton providing constant pressure.

Sellers’ teammates on D have his back though. The Gamecocks are very much game when it comes to defense, allowing under 200 yards passing per game and coming off a win over Oklahoma where they allowed just 9 points and scored two defensive touchdowns.

This game might be won through defense alone, on both sides. With that, the Over/Under of 44 could be a tempting Under for bettors at Bovada.

Either way, oddsmakers are keeping it close with less than a field goal difference when it comes to the spread between Texas A&M and South Carolina.

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Having caught up with our Week 10 college football analysis, let’s revisit our preview and predictions from Week 9. Bovada’s Sports Welcome Bonus is ready for all new players to get in on the NCAA football action. Making that first deposit with crypto gets you even bigger bonus cash too. Take a walk

*Odds subject to change